New method for absolute spinal cord ischemia protection in rabbits
نویسندگان
چکیده
منابع مشابه
Spinal Cord Ischemia in Rabbits
Background and Purpose: The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the eifects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood ...
متن کاملIschemic Preconditioning Protects against Spinal Cord Ischemia-Reperfusion Injury in Rabbits by Attenuating Blood Spinal Cord Barrier Disruption
Ischemic preconditioning has been reported to protect against spinal cord ischemia-reperfusion (I-R) injury, but the underlying mechanisms are not fully understood. To investigate this, Japanese white rabbits underwent I-R (30 min aortic occlusion followed by reperfusion), ischemic preconditioning (three cycles of 5 min aortic occlusion plus 5 min reperfusion) followed by I-R, or sham surgery. ...
متن کاملCyclin D1 and Cdk4 protein induction in motor neurons after transient spinal cord ischemia in rabbits.
BACKGROUND AND PURPOSE The mechanism of spinal cord injury has been thought to be related to the vulnerability of spinal motor neuron cells against ischemia. However, the mechanisms of such vulnerability are not fully understood. We hypothesized that spinal motor neurons might be lost by programmed cell death and investigated a possible mechanism of neuronal death by detection of double-strand ...
متن کاملLumbar CSF Drainage for Spinal Cord Protection
As disease awareness and diagnostic modalities continue to improve, the prevalence of thoracic aortic disease (aneurysm and dissection) is increasing, affecting up to 16.3 individuals per 100,000 per year. 1,2 However lifesaving surgery may be, paraplegia remains one of the most devastating complications of thoracoabdominal aortic surgery and is associated with a significant increase in both mo...
متن کاملThe Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2011
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2011.04.043